Deadly UPS Plane Crash in Louisville: What We Know

LOUISVILLE, KY — A UPS plane tragically crashed on Tuesday, November 5, 2025, around 5:15 PM as it departed from Louisville Muhammad Ali International Airport, en route to Honolulu’s Daniel K. Inouye International Airport. The crash resulted in multiple fatalities and significant damage in the surrounding area.

Casualties: As of Wednesday morning, reports confirm at least nine fatalities, including all three crew members aboard. Additionally, 11 individuals sustained injuries, and at least 16 are unaccounted for.

Crash Details: The McDonnell Douglas MD-11, which was approximately 34 years old, had been fully loaded with around 38,000 gallons of fuel at the time, significantly contributing to the intense blaze that ensued. Witnesses reported seeing flames before the impact.

Emergency Response: Over 200 first responders from various departments, including Okolona Fire Department and Louisville Metro Fire, were deployed to manage the extensive fire and search efforts. The fire took about six hours to control, impacting businesses along Grade Lane and Fern Valley Road.

Investigation: The National Transportation Safety Board has initiated an investigation into the crash. It remains unclear what caused the plane to catch fire.

Public Safety Measures: A shelter-in-place order was issued, affecting areas extending to southern Indiana. Residents in the immediate vicinity have been advised to avoid consuming water until further notice.

State of Emergency: Kentucky Governor Andy Beshear declared a state of emergency, allowing expedited resource allocation for recovery efforts.

Updates and Information: Authorities continue to monitor the situation and provide updates. A family reunification center has been established for those affected.

For the latest information, stay tuned to local news outlets.